V1a Receptor

V1a Receptor Related Products (21):

By Type:	Pan (2) Selective (4)
By Effects:	Inhibitor (1) Agonists (4) Antagonists (14) Activators (2)

Cat. No.	Product Name	Effect	Purity

HY-18347A

Conivaptan hydrochloride	Antagonist	99.95%
Conivaptan (hydrochloride) is a non-peptide antagonist of vasopressin receptor, with K_i values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively.

HY-18345

SR 49059	Antagonist	99.33%
SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a K_i vaule of 1.4 nM.

HY-15010

L-371,257	Antagonist	99.34%
L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (K_i=19 nM) and vasopressin V1a receptor (K_i=3.7 nM).

HY-109024

Balovaptan	Antagonist	99.89%
Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with K_is of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.

HY-105239

Selepressin	Agonist	98.17%
Selepressin (FE 202158) is a selective vasopressin V_1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock.

HY-111225

VA-111913	Antagonist
VA-111913 (VT-913) is a vasopressin receptor V1A antagonist (K_i = 1.74 nM). VA-111913 reduces uterine contractions and improves uterine blood flow by inhibiting vasopressin, thereby alleviating dysmenorrhea. VA-111913 can be used for research on menstrual pain.

HY-105239A

Selepressin acetate	Agonist	98.04%
Selepressin (FE 202158) acetate is a selective vasopressin V_1A receptor agonist. Selepressin acetate is a potent vasopressin. Selepressin acetate can be used in the study of septic shock.

HY-19381

WAY-151932	Agonist	99.87%
WAY-151932 is a vasopressin V₂-receptor agonist with IC₅₀ of 80.3 nM and 778 nM in human-V₂ binding and V_1a binding assay.

HY-105685

SRX246	Antagonist	99.76%
SRX246 is a potent, BBB-penetrant, highly selective vasopressin 1a (V1a) receptor antagonist (K_i=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors. SRX246 can be used for treatment of stress-related disorders.

HY-P4678

(Phe2,Orn8)-Oxytocin	Agonist	99.55%
(Phe2,Orn8)-Oxytocin is a selective V1 vasopressin agonist. (Phe2,Orn8)-Oxytocin induces a sustained contractility of rabbit epididymis with EC₅₀ value of 280 nM.

HY-108678

TC OT 39	Antagonist
TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC₅₀=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an K_i value of 330 nM. TC OT 39 exhibits sedative effects in mouse models.

HY-12981

RG7713	Antagonist	99.92%
RG7713 (RO5028442) is a highly potent, selective and brain-penetrant Vasopressin 1a (V1a) receptor antagonist with K_is of 1 nM (hV1a) and 39 nM (mV1a).

HY-P5213

Vasopressin Dimer (parallel) TFA	Activator	99.55%
Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR.

HY-P4683

(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin	Antagonist
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats.

HY-168742

V1a/V2 antagonist 1	Antagonist
V1a/V2 antagonist 1 (Compound 18j) is an orally active dual V1a and V2 receptor antagonist with high binding affinity for both receptors (K_i: 0.13 nM for hV1a, 0.53 nM for hV2 and 0.5 nM for mV1a; IC₅₀: 2.2 nM for hV1a). V1a/V2 antagonist 1 inhibits Oxytocin (HY-17571)-induced scratching behavior in mice.

HY-P5214

Vasopressin Dimer (anti-parallel) TFA	Activator
Vasopressin Dimer (anti-parallel) TFA is an anti-parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (anti-parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR.

HY-P5010

(D-Arg8)-Inotocin	Antagonist
(D-Arg8)-Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V_1aR), with a K_i of 1.3 nM. (D-Arg8)-Inotocin shows more than 3000-fold selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R.

HY-124275

ML389	Antagonist
ML389 is a highly selective vasopressin 1a (V1a) receptor antagonist (IC₅₀=40 nM). ML389 is promising for research of central nervous system disorders such as anxiety, depression, and post-traumatic stress disorder (PTSD).

HY-109133

Pecavaptan	Inhibitor
Pecavaptan, a chemical probe, is an orally active and dual antagonist of V1a/V2 receptor (K_i=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema.

HY-18347

Conivaptan	Antagonist
Conivaptan (YM 087 free base) is antagonist for vasopressin V1A receptor and vasopressin V2 receptor. Conivaptan ameliorates congestive heart failure, improves cardiac systolic function.

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